To Your Health
December, 2011 (Vol. 05, Issue 12)
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Antioxidant Defense: Fighting Cancer Naturally

By James P. Meschino, DC, MS

According to an important study appearing in a recent issue of the European Journal of Nutrition, individuals who were taking antioxidant supplements at the start of the 11-year study period had a 48 percent reduction in the risk of cancer mortality (death).

In addition, the risk of dying from all causes (all-cause mortality) was 42 percent lower among antioxidant supplement users. Of interest is the fact that taking only a basic multiple vitamin and mineral supplement (i.e., one not enriched with meaningful doses of antioxidants) did not confer any protection against cancer or all-cause mortality. Let's take a look at some of the lifestyle factors impacting your risk of cancer and then circle back to how antioxidants can play an important role in cancer defense.

Diet, Lifestyle and Cancer

There is a marked overall difference in total cancer incidence between developed and developing countries. Cancers of the cervix, liver, stomach and mouth are the most common cancers in developing countries. In developed countries, lung cancer, colon cancer, breast cancer, prostate cancer and bladder cancer are the leading cancers of clinical significance. (Skin cancer has the highest incidence of all cancers, but only melanomas present significant mortality risk.) Worldwide, the incidence of colon cancer varies 20-fold (highest in the U.S.; lowest in India), and breast cancer varies seven-fold (highest in U.S. Hawaiians; lowest in Israeli non-Jews). In Europe, total cancer rates are approximately 50 percent lower in Greece compared to Germany.

Evidence that this variation in cancer incidence is primarily a result of environmental and lifestyle factors, rather than genetic factors, is derived from several lines of investigation. First, studies of migrants moving from low- to high-risk areas have shown that migrants acquire the cancer incidence rate of their new country within a relatively short period of time. For example, colon cancer incidence can increase up to 20-fold within a single generation. Rising and declining incidence of tobacco-associated lung cancer has also been shown.

Forty years ago, the incidence of colon cancer in Japan was extremely low and rare. Today, Japanese men living in Japan have colon cancer rates twice as high as seen in the United Kingdom. Clearly, there has been too little time for the Japanese gene pool to change sufficiently to account for this sudden rise in colon cancer incidence. However, the affluence witnessed in Japan after World War II brought with it significant changes in terms of dietary patterns (e.g., more meat consumption, less fiber consumption) that mirrors the dietary patterns of much of the Western world, where colon cancer is the second-leading cause of cancer death (after lung cancer). A similar transformation has occurred in Hong Kong, where rates of colon, breast, prostate, endometrium and lung cancer have gone from being among the lowest in the world to incidence rates similar to that of the United States. Again, recently acquired affluence has brought about a Westernized shift in dietary and lifestyle practices in this region.

Additionally, since the 1940s, many population studies have examined the association between diet and cancer. Taken together, the evidence suggests that 32-35 percent of cancers are attributed to nutrition, although the contribution of diet to specific types of cancer varies from as little as 10 percent for lung cancer to 80-90 percent for colorectal cancers. These studies suggest that nutrition appears to account for approximately 50 percent of breast cancers and 75 percent of prostate cancers.

What is under intense investigation at this time are studies examining individual dietary nutrients to help discern which dietary factors promote cancer and which may prevent cancer. There is broad consensus at this time that factors such as obesity and alcohol consumption increase cancer risk, while consumption of fruits and vegetables reduces cancer risk. Experts also agree that cancer arises from a complex interaction of genetic factors, individual metabolic characteristics and diet.

Antioxidants for Cancer Defense

To help decipher the complex relationship between diet and cancer, the European Prospective Investigation into Cancer and Nutrition (EPIC) Study was initiated in 1992. The EPIC Study has been following over 500,000 people living in 10 European countries (Denmark, France, Germany, Greece, Italy, The Netherlands, Norway, Spain, Sweden and the United Kingdom). A great deal of data including weight, height, lifestyle factors (including dietary behaviors) personal history and blood samples were collected at the beginning of the study, with periodic follow-up of these parameters collected on an ongoing basis.

In the 2011 EPIC Study update, published in the European Journal of Nutrition, researchers showed impressive evidence for the use of antioxidant supplements in the prevention of cancer and all-cause mortality, as mentioned above. In the 2011 report, scientists based these findings on the analysis of 23,943 subjects, all free of cancer and heart disease at the start of the study.

After 11 years of monitoring, there were 1,101 deaths, of which 513 were from cancer and 264 from cardiovascular conditions. After controlling for other confounding variables, researchers noted that individuals who voluntarily started taking antioxidant supplements prior to the beginning of the study showed a significantly reduced risk of both cancer and all-cause mortality. Researchers affiliated with the EPIC Study indicate that research such as this, which involves following a large number of subjects for many years, is the only valid method to evaluate the influence of diet, lifestyle and environmental factors on cancer risk.

Take-Home Points

The EPIC Study suggests that antioxidant supplements have the potential to help reduce the risk of cancer, heart disease and all-cause mortality. Many experimental and preclinical studies have shown impressive anti-cancer and anti-heart-disease mechanisms through which antioxidants may reduce the risk of these and other diseases.

The first landmark clinical study of its kind to show the importance of supplementation with cancer patients was published in Molecular Aspects of Medicine in 1994. Researchers showed that antioxidant supplements could play a key role in preventing the recurrence of breast cancer. Over the years, other studies have shown important anti-cancer benefits of antioxidant supplements when administered to patients with prostate cancer, cervical dysplasia, oral leukoplakia, atrophic gastritis, and other cancerous and precancerous conditions.

If you take a standard multiple vitamin and mineral each day for the purposes of increasing well-being and energy, and decreasing the risk of degenerative diseases, keep in mind that the EPIC Study suggests that unless a multiple vitamin / mineral supplement is enriched with meaningful doses of antioxidants, then it is unlikely to provide significant anti-cancer and anti-heart disease properties. Accordingly, you should review the antioxidant dosages contained in the supplements you are taking with your chiropractor to ensure they contain meaningful concentrations of antioxidants (e.g. ,vitamin E succinate: 400 IU; vitamin C: 500-1,000 mg; selenium: 100-200 mcg; etc.). This one simple intervention may help reduce your risk of cancer by almost 50 percent and all-cause mortality by 42 percent over the ensuing decades. Talk to your doctor of chiropractic for more information.

James Meschino, DC, MS, practices in Toronto, Ontario, Canada and is the author of four nutrition books, including The Meschino Optimal Living Program and Break the Weight Loss Barrier.